Panthers have blown some pretty large leads this year, squeaking out some games that looked like blowouts. With that in mind Manning is playing all 4 quarters if he's healthy. He's more likely to bring them back from the dead than Osweiler.
Since I talked all of that crap about the Patriots easily beating the Broncos I'm going to say the Panthers will easily win this game. You're welcome Denver fans.
Has that ever even happened? I can't recall watching a SB where the backup played significant snaps. My memory ain't so good, though.